Description
Contributes to normal blood formation, normal homocysteine metabolism, normal cell division, and normal maternal tissue growth during pregnancy.
How It Works
5-MTHF is the circulating, blood-brain-barrier-permeable form of folate and the direct methyl donor for the methionine synthase reaction. It requires no enzymatic conversion before use.
Why This Form
The metabolically active form. Synthetic folic acid depends on dihydrofolate reductase for conversion, an enzyme whose capacity is rate-limited in humans and varies with MTHFR genotype. B12 is included because high folate intake can mask the haematological signs of B12 deficiency.
What we rejected: Folic acid. Beyond the conversion bottleneck, unmetabolised folic acid appears in circulation at higher intakes.
The Research Behind It
Comparative bioavailability trials of 5-MTHF against folic acid, with plasma folate response as the measured endpoint.
What The Evidence Does Not Show
MTHFR polymorphism prevalence is a population statistic. We cite it and do not suggest that any individual reader carries a variant. If you are pregnant or planning pregnancy, discuss folate intake with your provider.
Supplement Facts
| Per Serving | Amount | % DV |
|---|---|---|
| Folate (as L-5-methyltetrahydrofolate, glucosamine salt) | 680 mcg DFE (400 mcg) | 170% |
| Vitamin B12 (as methylcobalamin) | 250 mcg | 10,417% |
† Daily Value not established. Percent Daily Values are based on a 2,000 calorie diet.
Other Ingredients
Microcrystalline cellulose (bulking agent), plant-derived capsule shell.
Every ingredient in this product is listed above. We use no proprietary blends, no titanium dioxide, no artificial colours and no artificial sweeteners. Our Sourcing Standard →
Warnings
If you are pregnant, nursing, or planning pregnancy, consult your healthcare provider before use.
References
A numbered reference list for this formulation is in preparation. In the meantime, you can review the published human trial literature directly:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
University Vitamins is an independent company. We are not affiliated with, endorsed by, or sponsored by any university or academic institution. Institution names appear solely to identify the source of the research referenced.
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