Description
Contributes to normal blood coagulation and to the maintenance of normal bones.
How It Works
Vitamin K2 is the cofactor for gamma-glutamyl carboxylase, the enzyme that activates the Gla protein family. Two of these — osteocalcin in bone and matrix Gla protein in vascular tissue — govern where calcium is deposited.
Why This Form
All-trans isomer, verified by HPLC, with the isomer ratio published on the certificate of analysis. This is the single most under-reported quality failure in the category.
What we rejected: Commodity MK-7 of undeclared isomer ratio. The cis isomer is biologically inactive, and material containing it is sold at the same milligram figure as all-trans without disclosure.
The Research Behind It
Multi-year human intervention trials measuring vitamin K carboxylation status, with carboxylated and undercarboxylated osteocalcin as primary markers and bone mineral density followed over three-year durations.
What The Evidence Does Not Show
Carboxylation status is a biomarker rather than an outcome. The vascular literature is mechanistically suggestive but not conclusive, and we present it that way.
Supplement Facts
| Per Serving | Amount | % DV |
|---|---|---|
| Vitamin K2 (as all-trans menaquinone-7) | 180 mcg | 150% |
† Daily Value not established. Percent Daily Values are based on a 2,000 calorie diet.
Other Ingredients
Microcrystalline cellulose (bulking agent), plant-derived capsule shell, rice hull concentrate (flow agent).
Every ingredient in this product is listed above. We use no proprietary blends, no titanium dioxide, no artificial colours and no artificial sweeteners. Our Sourcing Standard →
Warnings
Contraindicated with warfarin and related vitamin K antagonist anticoagulants. Consult your physician before use.
References
A numbered reference list for this formulation is in preparation. In the meantime, you can review the published human trial literature directly:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
University Vitamins is an independent company. We are not affiliated with, endorsed by, or sponsored by any university or academic institution. Institution names appear solely to identify the source of the research referenced.
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