Description
Evidence Tier · Randomized Controlled Trials
Vitamin D3 paired with vitamin K2 as menaquinone-7 and a modest dose of calcium, in one capsule.
What It Does
Supports normal calcium absorption, bone maintenance, and immune function.*
How It Works
Vitamin D3 increases intestinal calcium absorption. Vitamin K2 activates osteocalcin, the protein that binds calcium into bone matrix. The two act in sequence.
Why This Form
D3 rather than D2, which raises serum 25(OH)D less efficiently. MK-7 rather than MK-4 for a longer serum half-life suited to once-daily use.
Clinical Evidence
A dose-response study established how much serum 25(OH)D rises per unit of daily cholecalciferol.¹ A three-year trial of MK-7 in postmenopausal women measured bone mineral density and strength.²
What The Evidence Does Not Show
The MK-7 trial used 180 mcg daily. This formula provides 100 mcg. 5,000 IU is a repletion-level dose. Have your serum vitamin D checked if you take it long term. Contraindicated with vitamin K antagonist anticoagulants such as warfarin.
Supplement Facts
| Per Serving | Amount | % DV |
|---|---|---|
| Vitamin D3 (cholecalciferol) | 125 mcg (5,000 IU) | 625% |
| Vitamin K2 (MK-7, menaquinone) | 100 mcg | † |
| Calcium (as calcium carbonate) | 210 mg | 16% |
| BioPerine® black pepper extract | 5 mg | † |
† Daily Value not established.
Other Ingredients
Microcrystalline cellulose, hypromellose (vegetable capsule).
Warnings
Do not use with warfarin or other vitamin K antagonists. Consult your physician if pregnant, nursing, or taking medication. Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
References
- Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-210. Creighton University and Boston University. PubMed 12499343
- Knapen MHJ, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24(9):2499-2507. Maastricht University. PubMed 23525894
Institution names identify where the cited research was conducted. University Vitamins is not affiliated with or endorsed by these institutions. Our Research Standard →
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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