Description
Evidence Tier · Randomized Controlled Trials
KSM-66 ashwagandha root extract at 600 mg, the branded extract and daily dose used in the key human trials, with supporting vitamins and botanicals.
What It Does
Helps the body manage everyday stress and supports restful sleep.*
How It Works
Withanolides in ashwagandha root appear to modulate the hypothalamic-pituitary-adrenal axis. Trials report lower serum cortisol alongside lower perceived stress scores.
Why This Form
KSM-66 is a full-spectrum root extract standardized to 5% withanolides. Using the same extract and dose as the trials matters, because ashwagandha preparations vary widely.
Clinical Evidence
A double-blind, placebo-controlled trial gave 300 mg KSM-66 twice daily for 60 days to adults with chronic stress and measured stress scales and serum cortisol.¹ A trial at the same dose measured sleep quality and sleep onset over 10 weeks.²
What The Evidence Does Not Show
Trials ran 8 to 10 weeks. The formula also contains L-arginine, maca, Panax ginseng and shatavari at doses below those studied on their own. Not for use in pregnancy. Rare cases of liver injury have been reported with ashwagandha.
Supplement Facts
| Per Serving | Amount | % DV |
|---|---|---|
| Vitamin D3 (as cholecalciferol) | 20 mcg | 100% |
| Vitamin B6 (as pyridoxine HCl) | 2.5 mg | 147% |
| Vitamin B12 (as methylcobalamin) | 25 mcg | 1042% |
| KSM-66® ashwagandha root extract (5% withanolides) | 600 mg | † |
| L-Arginine | 300 mg | † |
| Maca root powder | 150 mg | † |
| Panax ginseng root powder | 100 mg | † |
| Shatavari root powder | 50 mg | † |
† Daily Value not established.
Other Ingredients
HPMC (vegetable capsule).
Warnings
Do not use if pregnant or nursing. Consult your physician if you have a thyroid or autoimmune condition, liver disease, or take sedatives or thyroid medication. Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
References
- Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. PubMed 23439798
- Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus. 2019;11(9):e5797. D.Y. Patil University School of Medicine. PubMed 31728244
Institution names identify where the cited research was conducted. University Vitamins is not affiliated with or endorsed by these institutions. Our Research Standard →
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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