Description
Evidence Tier · Mixed Results
Black cohosh, red clover, sage and soy isoflavones with supporting botanicals.
What It Does
Supports comfort during menopause.*
How It Works
Red clover and soy isoflavones are plant compounds that bind estrogen receptors weakly. Black cohosh and sage act on serotonergic and other pathways involved in temperature regulation.
Why This Form
Combines the botanicals that have been tested most in menopausal women.
Clinical Evidence
A Cochrane review assessed black cohosh trials for menopausal symptoms.¹ An open-label trial at a Swiss clinical center gave sage leaf extract to menopausal women and recorded hot flush frequency.²
What The Evidence Does Not Show
The Cochrane review found insufficient evidence that black cohosh outperforms placebo. The sage trial had no placebo group. This is our lowest evidence tier and we label it as mixed.
Supplement Facts
| Per Serving | Amount | % DV |
|---|---|---|
| Red clover extract (1%) | 400 mg | † |
| Sage leaf extract (2.5%) | 200 mg | † |
| Black cohosh root extract | 160 mg | † |
| Dong quai root extract (1%) | 150 mg | † |
| Licorice root extract (1%) | 150 mg | † |
| Chasteberry fruit extract (0.5%) | 50 mg | † |
| Blessed thistle, red raspberry | 50 mg each | † |
| Soy isoflavones | 30 mg | † |
| Wild yam extract (16%) | 15 mg | † |
| Trans-resveratrol | 1 mg | † |
† Daily Value not established.
Other Ingredients
Gelatin (bovine), microcrystalline cellulose, vegetable magnesium stearate, silicon dioxide. Contains soy.
Warnings
Not for use if pregnant or nursing. Do not use if you have a hormone-sensitive condition, liver disease, or high blood pressure, or take anticoagulants, without consulting your physician. Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
References
- Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev. 2012;(9):CD007244. University of South Australia. PubMed 22972105
- Bommer S, Klein P, Suter A. First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes. Adv Ther. 2011;28(6):490-500. PubMed 21630133
Institution names identify where the cited research was conducted. University Vitamins is not affiliated with or endorsed by these institutions. Our Research Standard →
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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